A Model Study by FT-IR of the Interaction of Select Cholate Dissolution Inhibitors with Poly(Norbornene-alt-Maleic Anhydride) and its Derivatives
22 August 1999
The fundamental nature of the interaction between the polymer matrix and the cholate based dissolution inhibitors (DIs) are being studied by Fourier Transform-Infrared (FT-IR) spectroscopy. It was found that the simple cholate derivatives (t-butyl cholate, t-butyl deoxycholate, and t-butyl chenodeoxycholate) undergo, in a blend with poly(norbornene-alt-maleic anhydride) and in a blend with the terpolymers poly(norbornene-alt-maleic anhydride-co-t-butylacrylate) and poly(norbornene-alt-maleic anhydride-co-acrylic acid), a stronger interaction as seen by shifts in the OH region of the spectra than do blends with dimeric or oligomeric cholates.